Who are you, and what do you do?
I was the original designer for EveryBlock, and before that I was a designer for apple.com. I'm from Kansas originally. When I lived in Lawrence, I helped create the original version of the Django web framework.
What hardware do you use?
My main machine is a 15" MacBook Pro 2.66GHz i7 with a 250GB SSD. Switching to a machine with an SSD has been the most significant updgrade for me since I started using computers. It's a more noticeable difference than any RAM, processor or OS upgrade over the years. It takes time out of literally everything I do all day. I use the laptop at work with a 23" LED Cinema Display, and when I travel for work I take this machine with me.
At home I have a 27" iMac 2.93 GHz i7 with 8GB of RAM, 200GB SSD and 1TB second drive which I use for archives of photos and project files. I've had a one-laptop setup for a long time, but it's a lot easier today to keep two machines in sync than it used to be. I keep current project files on Dropbox, and for the few apps I use everyday that don't have some kind of built-in sync support, I store the library files in a Dropbox folder. I still do a lot of work at home, and I like not having to shuttle and unpack and reassemble the laptop setup between home and office. Also, I've got Boot Camp and Steam for Mac on that machine for games. I've got a stockpile of old games from various Steam sales that I missed out on during all those years of being a Mac user and a console gamer.
I have a Logitech Performance MX mouse at home and at work. It's hands-down the best mouse I've ever used. I have a Seagate FreeAgent Go 500GB drive at home and at work, which are used as Time Machine backups for each of my two machines.
I also have a Mac Mini in my living room, which I mainly use to run XBMC for video. It's connected to a ReadyNAS NV+ RAID device which has a lot of video on it, and years worth of collected music that I don't listen to anymore since it's all on Rdio now. I invested in this whole setup 5 years ago or so, and it's worked well since then, but it's cumbersome and expensive, and as soon the video content landscape settles down and Netflix or Amazon or Hulu or somebody can offer me enough of the content I want at a quality level I'm happy with, I'm ready to ditch it all in a heartbeat for a tiny box and some streaming services. Roku is getting a lot of traction these days, and Rdio just released an app for it, so I might try that out soon.
I inherited a mild case of audiophile disease, so I have a Beresford TC-7520 DAC connected to the iMac at home, which is the only digital audio converter I could find with both pre-amp outputs and a headphone amp with volume control so it can run both a pair B&O Beolab 4000 powered speakers and my Sennheiser HD 650 headphones. I have a much cheaper setup at work, with a NuForce headphone amp and a pair of Grado SR60 headphones. I could go on with the audio equipment, but this is already getting kind of embarrassing.
I have an iPhone 3GS. My wife had her phone stolen right about when the iPhone 4 came out, so I gave her my AT&T upgrade and by the time my turn comes around again it'll be time to wait and see what's out next. I use it all the time, for reading on the train with the Kindle app, music with Rdio, Twitter, etc. I have the same white whine as everybody else in San Francisco that AT&T 3G service doesn't actually work very well for actual phone calls. I won't switch to Verizon though, because I secretly like having an excuse for not having to talk on the phone.
And what software?
I use Photoshop and Illustrator CS5. I prefer Illustrator for wireframes and rough comping. Photoshop only works for me when I already know exactly what I want. Illustrator is much more forgiving about changing your mind and thinking as you go. It's still a damn shame that there isn't a stable, mature web design app with vector drawing tools and pixel-perfect export control.
I recently started using Sparrow for email, since all my email is Google Accounts-based. I like a lot of things about the way it handles Gmail accounts, but it's still a little rough around some edges. I'm intrigued by the screenshots of Mail in Mac OS X Lion that look very similar to Sparrow in terms of iOS-influenced layout.
I use TextMate for the code I still write, which is less and less these days. I recently started using Tower for dealing with Git repositories, which I'm very impressed with. It inherits some of the built-in complexity of Git itself, but it's a very solid and comprehensive GUI for version control that makes me feel a little less like a kindergartner in a restaurant kitchen every time I use Git. I use Notational Velocity synced to Simplenote as a digital notebook. I'm a die-hard Safari user, but I recently started using Chrome as well, just for keeping my work account for Google Docs from interfering with my personal Google accounts. Google Apps are a great service, but they've really mangled the way they handle multiple accounts recently. I use iCal to manage and sync all my Google calendars over CalDAV.
I distract myself with the new Twitter Mac app (which I like everything about except the current dock icon) and Reeder for Mac, which has grown on me a lot since the early releases. I use the excellent LittleSnapper from Realmac software as a visual scrapbook of designs and images that I want to steal from... er... be inspired by later. I also love a site called Lookwork, which works like a kind of visual RSS reader, extracting images from feeds and displaying them in a light table layout for quick skimming.
What would be your dream setup?
I'm still waiting for a simpler solution for syncing accounts and data between multiple machines. Dropbox and services like Rdio and MobileMe (despite its shortcomings, I still think the sync feature is magic sometimes) have made a huge difference, but I still dream of just logging in to any machine (from a desktop to an iPhone), and having everything I need in that context (apps, documents, media, etc) already there.