Who are you, and what do you do?
What hardware do you use?
Primary work computer: 27" iMac (i7 processor, 8GB RAM) with 22" secondary monitor, primary laptop is a 13" Macbook Pro (Core 2 Duo, 4 GB RAM). I have a 60Mb/s cable Internet connection through RCN. I have a number of backup machines, mostly used for testing, including a PC running Windows XP, a Chromebook, and a MacBook. I also utilize a large number of phones and tablets for testing, most of which are located at Filament Group, the folks who are behind jQuery Mobile.
I also have multiple Mac Minis that I use for watching media. One is hooked to a projector that is capable of displaying 720p video (BenQ W500), another is hooked to a 19" LCD that is in front of my elliptical.
In my kitchen I have an iPod/iPhone dock and speakers that I can hook my iPhone into to play music while I cook. I have a similar dock in my car.
I have a 5 Bay RAID-5 NAS (Thecus N5200BR) with 5 1TB drives in it (giving me about 3.6 TB of storage, which is currently all used). I backup all my media to this device and keep a spare hot swap drive in case of hard drive failure. I keep an extra backup of all my documents on Dropbox.
And what software?
For everyday computer use I use Firefox for browsing (holding Google Mail and Calendar in app tabs). I do a lot of writing in Google Docs, my presentations in Keynote, and my blog post authoring in Textmate. I use Skype, Google Chat (inside GMail), and IRC (using IRSSI in a screen session) for communication and Gyazo for screenshot sharing.
For development I use Chrome, vim (vim config), Textmate, and iTerm2. I keep a number of browsers open at all times, multiple versions of Firefox, Chrome, Opera, and Safari. I run VMWare Fusion with even more browsers inside (including multiple versions of IE, Firefox, Opera, Chrome, and Safari). I use MAMP to easily run a simple, local, web server and MySQL DB to help with testing. I store all my code in Git (on Github, oftentimes in private repos) and back it up in Dropbox.
On my phone I have the following apps on my home screen, from top left to bottom right: iPod, Clock, Notes, Camera, Settings, NOAA (opens weather.gov), Calendar, Twitter, Foursquare, Carcassonne, MassTransit (gives me Boston bus GPS positions), Yelp, Facebook, and iSSH (can SSH into servers, use IRC), Maps, Safari, Messages, and Phone.
For acquiring media I use iTunes, Amazon MP3, Netflix streaming, and Usenet. Specifically for Usenet I use SABnzbd+, running on one of my Mac Minis, connecting to Giganews, and pulling from NZBs.org or Newzbin.
For games I play Starcraft 2 (id: frowny.396, I'm a Silver Protoss), Minecraft, and some iPhone games (including Carcassonne and Words with Friends). Word of warning: I'm currently ranked around 50th worldwide at Carcassonne, my ID is my email address: jeresig at gmail dot com.
What would be your dream setup?
I'm very close to it now, although I do have a couple wishes. I wish my MacBook had built-in 3G capabilities, I wish it was easier to type on my iPad, I wish Chrome was a better browser, I wish SABnzbd+ was smart enough to not re-download files, I wish my iPhone was faster, I wish I didn't need a dongle to do a presentation with my MacBook, I wish Boxee didn't crash so much, I wish my car accepted audio input, I wish Dropbox could backup my Google Docs and Mail.